Circrhobtb3
WebJun 2, 2024 · The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Rising evidences bespeak that circular RNAs are indispensable in regulating cellular biological behaviors and engaging in diseases' occurrence. WebFeb 11, 2024 · Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer Jiaxin Chen, Yizheng Wu, +9 authors Zhangfa Song Biology, Medicine Theranostics 2024 TLDR Findings indicate that circRHOBTB3 exerts suppressive effects on CRC aggressiveness through the …
Circrhobtb3
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WebFeb 11, 2024 · circRHOBTB3 was produced by splicing and circularization of the host gene RHOBTB3. As a Rho GTPase-family ATPase, the host gene RHOBTB3 is involved in membrane transport [ 8, 9] and proteasomal degradation [ 10] and can inhibit tumor growth by promoting the proteasomal degradation of HIF-α in renal cancer [ 11 ]. WebThe Crossword Solver found 20 answers to "Heartthrob?", 5 letters crossword clue. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. …
WebJul 27, 2024 · We aimed to explore the functional role of circular RNA RHOBTB3 (circRHOBTB3) in ovarian cancer. The expression of circRHOBTB3 was detected by real-time quantitative PCR (RT-qPCR). Then, the localization of circRHOBTB3 in ovarian cancer cells was identified by cell fractionation assay. WebFigure Legend Snippet: circRHOBTB3 promotes PANC-1 cell proliferation by activating autophagy response. a The protein level of p62 and LC3B were determined by western blotting in PANC-1 cells transfected circRHOBTB3 overexpressing vector with or without 3-Methyladenine (3-MA, 2.5 mM, 24 h) treatment. b The mCherry-GFP-LC3B labeled …
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WebMar 21, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4. In conclusion, this novel NR1H4/circRHOBTB3/IGF2BP3 axis may provide new insights into CC pathogenesis. PMID: 36939994
WebJun 29, 2024 · CircRHOBTB3 is downregulated in HCC and may suppress cell proliferation by reducing miR-18a production. Introduction Hepatocellular carcinoma (HCC) is a major … diabetic alert service dog trainingWebJul 30, 2024 · Circular RNAs (circRNAs) have emerged as significant regulators in human cancers. We aimed to explore the functional role of circular RNA RHOBTB3 (circRHOBTB3) in ovarian cancer. The expression of circRHOBTB3 was detected by real-time quantitative PCR (RT-qPCR). cindy holscher ksWebJan 13, 2024 · The circRHOBTB3 probe was incubated with streptavidin magnetic beads (Beaver, Suzhou, china) for 2 h to generate probe-coated beads, then incubated with cell lysates, followed by eluted with Trizol (Takara, japan), and qRT-PCR. for miR-654-3p pulled down, about 1 × 10 7 cells were collected, lysed, sonicated, and incubated with … diabetic alkaline bathsWebMechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to ... cindy holscher twitterWebNational Center for Biotechnology Information diabetic all broth dietWebFeb 11, 2024 · circRHOBTB3 is secreted outside of tumor cells and suppresses CRC cells in vitro and in vivo. ( A) Expression of circRHOBTB3 in CRC or normal colonic epithelial … diabetic alert tattoo for teenWebFeb 11, 2024 · circRHOBTB3 is secreted outside of tumor cells and suppresses CRC cells in vitro and in vivo. (A) Expression of circRHOBTB3 in CRC or normal colonic epithelial … cindy holmstrom