Web10. Chaparro M, Panes J, Garcia V, et al. Long-term durability of infliximab treatment in Crohn’s disease and efficacy of dose “escalation” in patients losing response. J Clin Gastroenterol. 2011;45:113–118. 11. Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. WebJan 3, 2024 · Several factors associated with an increased clearance of the drug and lower concentrations have been identified in population pharmacokinetic studies of infliximab, such as body weight, the presence of anti-infliximab antibodies, albumin concentrations (Matsuoka et al., 2024; Hanzel et al., 2024), the concomitant use of …
Concomitant Use of Immunomodulators Affects the Durability of ...
WebDec 30, 2013 · Infliximab often requires dose escalation to maintain response. Studies regarding long-term durability and dose escalation patterns for psoriasis are few. We sought to evaluate dose escalation... WebBackground Infliximab (IFX) discontinuation is not uncommon during the first year of treatment due to inadequate drug concentrations and anti-IFX antibodies (ATI). Both combination therapy and proactive therapeutic drug monitoring (pTDM) are used to decrease ATI and increase IFX durability. caffeine outlawed
Long-term durability and dose escalation patterns …
WebOct 21, 2024 · In the study, the drug survival of infliximab versus adalimumab either as first- or second-line treatment for inflammatory bowel disease (IBD) was investigated. The authors identified therapeutic drug monitoring (TDM) as the only factor associated significantly with greater drug survival. WebDec 30, 2013 · Among patients treated with infliximab over a 3-year period in the Esposito et al. [9] study who had a dose escalation (24.5%), 11 had an interval decrease to \ 8 … WebObjectives: The aim of the study was to evaluate infliximab (IFX) dosing and treatment durability relative to luminal disease burden in patients with inflammatory bowel disease. … caffeine oolong vs black