WebHemistepsin A (HsA) is a sesquiterpene lactone isolated from Hemistepta lyrata Bunge (Compositae). Here, we report that HsA is a PDK1 inhibitor can reduce the growth of colorectal cancer and consequent activation of mitochondrial ROS-dependent apoptotic pathway both in vivo and in vitro. Computational simulation and biochemical assays … WebDec 5, 2024 · Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway 2024, Archives of Biochemistry and Biophysics Show abstract Effect of Sorbus domestica and its active constituents in an experimental model of colitis rats induced by acetic acid
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WebDec 14, 2024 · Hemistepsin A (HsA) is a sesquiterpene lactone isolated from Hemistepta lyrata Bunge (Compositae). Here, we report that HsA is a PDK1 inhibitor can reduce the … Webpromote bacterial clearance.hemistepsin A, lupiwighteone may be prom ising therapeutic targets in psoriasis treatment. European Journal of Molecular & Clinical Medicine ISSN 2515 -8260 Volume 08, Issue 03, 2024 1964 Introduction Autophagy is the cellular µµhousekeeping ¶¶ process responsible for the degradation of ... lawn mower vs snow
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WebFeb 5, 2016 · Hemistepsin A (HsA) is a sesquiterpene lactone isolated from Hemistepta lyrata (Bunge) Bunge. We investigated the anti-inflammatory effects of HsA and sought to determine its mechanisms of action in macrophages. HsA pretreatment inhibited nitric oxide production, and reduced the expression of iNOS and COX-2 in Toll-like receptor ligand ... WebHemistepsin A (HsA) is a guaianolide sesquiterpene lactone that inhibits hepatitis and liver fibrosis. We evaluated the effects of HsA on liver X receptor (LXR)-mediated hepatic lipogenesis in... WebThe two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity ... lawn mower vs finish mower