Hif2 overexpression
WebConsistent with this, overexpression of Sp1 increased endoge-nous Atp7a mRNA and protein expression and stimulated Atp7a, Dmt1, and Dcytb promoter activity. Site-directed mutagenesis and functional analysis of a basal Atp7a promoter construct revealed four functional Sp1 binding sites that were necessary for Hif2 -mediated induction of promoter ... Web22 de jan. de 2024 · HER2 overexpression in MCF7 cells leads to an increase in HIF-2α but not HIF-1α expression in normoxia and an increased upregulation of HIF-2α in …
Hif2 overexpression
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WebOverexpression of lncRNA HIF2PUT significantly attenuated the proliferation, migration and invasion of osteosarcoma stem cells. Furthermore, we demonstrated that lncRNA overexpression inhibited the sphere-formation of osteosarcoma stem cells by downregulating HIF-2α. These findings suggest that lncR … Web22 de jan. de 2024 · HER2 overexpression in MCF7 cells leads to an increase in HIF-2α but not HIF-1α expression in normoxia and an increased upregulation of HIF-2α in hypoxia. Global gene expression analysis showed that HER2 overexpression in these cells promotes an exaggerated transcriptional response to both short-term and long-term …
WebDownload scientific diagram Effect of Hif2 ␣ overexpression on Atp7a promoter activity. Hif2 ␣ expression vector was co-transfected into IEC-6 cells along with WT or mutant … Web21 de fev. de 2024 · The finding is consistent with the notion that overexpression of osteoblastic HIF2 inhibits bone resorption by increasing the Opg/Rankl ratio. 8. More …
Web5 de out. de 2024 · Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive … Web1 de set. de 2024 · Alzheimer’s disease (AD) Resilient individuals are characterized by having a degree of amyloid plaques at level with that of demented individuals, but a …
WebThe HIF2 ␣ overexpression system was thus utilized in cotransfection experiments using the wild-type Ϫ 224/ ϩ 88 bp promoter construct and additional constructs with specific deletions of the ...
Web15 de jan. de 2015 · HAF overexpression in mice increased CRCC growth and metastasis. Clinically, HAF overexpression was associated with poor prognosis. Taken together, our results show that HAF is a specific mediator of HIF2 activation that is critical for CRCC development and morbidity. order by chronologyWeb6 de out. de 2024 · Furthermore, knockdown of TEAD1/3/4 inhibited ccRCC cell growth whereas overexpression of TEAD4 rescued ccRCC cell growth in the presence of XMU … order by chooseWeb19 de out. de 2024 · Dickkopf-1 (DKK-1), a Wnt pathway inhibitor, and L685,458, an inhibitor of the Notch pathway, reversed the resistance to PTX and stem phenotype conversion … irc bouncer hostWeb18 de mar. de 2024 · To independently examine the effects of HIF1 and HIF2 on COX2 expression, we cotransfected the HIF1 overexpression plasmid or HIF2 … irc boyWeb24 de jun. de 2004 · Similarly, in A498 cells HIF2 overexpression had minimal impact on radiosensitivity (dose modifying factor, 1.15; data not shown). There was no difference in the radiosensitivity of VHL-ve and normal CHO cell lines (data not shown). Thus, overexpression of HIFs had only a small effect on radiosensitivity. irc bouncersWebDownload scientific diagram HIF2 overexpression in ISC-enriched duodenal organoid cultures. (A) Experimental design to generate 3D murine small intestinal organoid model … irc boatWeb26 de abr. de 2013 · A Hen's egg test-chorioallantoic membrane model of angiogenesis and invasion indicated a local expression of HIF-1β and implies a biological relevance of … order by characters sql